Johnson is headed to injured reserve with the hope he will be able to return later this season.
Johnson's injury likely means the Cardinals will be even more reliant on Palmer to win with his arm, which should benefit San Francisco in their matchups against the 38-year-old quarterback. Kerwynn Williams, Andre Ellington and Elijhaa Penny made up the running back depth before the roster moves were made.
Johnson injured his wrist in the season opener against the Detroit Lions.
The time frame given for his recovery is eight to 12 weeks or two to three months. He must spend at least eight weeks on IR, which at the earliest would allow a return to the field November 7. Chris Johnson was cut by the Cardinals after the preseason.
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Arians was referring to Johnson's rookie season, when he took over as starter when Chris Johnson went down with a knee injury.
Johnson's x-rays came back negative, but the wrist sprain still could keep him out for an extended period. Williams scored the team's only rushing touchdown against the Lions while finishing with 10 yards on five carries.
Before 2015, Johnson had never missed a game because of an injury.
Schefter added Johnson still has a chance to return this season. Last season, David Johnson led the National Football League in yards from scrimmage and touchdowns. Without the threat of Johnson in the backfield, the Cardinals' offense will be forced to rely on the pass. The former third-round pick out of Iowa recorded career-highs in receptions (54), receiving yards (559), and touchdowns (4) last season. Foster played in three games for the Patriots in 2016 and had six carries for 23 yards.