Israel has carried out almost 100 strikes in Syria since the beginning of the civil war there - many against convoys attempting to transfer precision weapons to Hezbollah, the country's air force chief told local media last month.
Jets flying over Lebanon overnight broke the sound barrier and Lebanese media reported that some Israeli jets had breached Lebanese airspace.
The reported attack took place on the 10th anniversary of Israel's destruction of a nuclear reactor in Syria.
There was no immediate comment from Israel, which has rarely confirmed or commented on such strikes.
Syrian Arab News Agency (SANA), has quoted a statement issued by General Command of the Army and Armed Forces affirming that the Israeli warplanes fired several rockets from the Lebanese airspace at 02.42 am on Thursday.
A few hours after the attack, the Syrian Army warned that there will be "dangerous repercussions", calling the airstrike an aggressive move that threatens the "security and stability in the region".
- In January Israeli planes hit a surface-to-air missile site and military complex near Damascus suspected of holding chemical agents.
The attack comes a day after United Nations human rights investigators said they had concluded a Syrian Air Force jet had dropped a bomb containing the nerve agent Sarin on a rebel-held town in April, killing at least 83 people.
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He said both leaders took " forward-looking " and "constructive" approach during the over an hour-long meeting. India and China are often described as geopolitical rivals, and the two remain locked in a border dispute.
Former IDF intelligence chief Amos Yadlin tweeted that the strike was "not routine", and that the destroyed facility was involved with the production of barrel bombs dropped on Syrian civilians.
The United States has accused Syria of using a research center in the area to develop and produce chemical weapons, which the Syrian government denies.
An Israeli military spokesperson refused to comment on Thursday morning's attack, saying the army does not comment on operational matters.
Israeli forces regularly launch attacks against positions of Assad's regime and Hezbollah militants inside Syria though most of the operations are not officially acknowledged by the Israel Defence Forces (IDF).
It added that Israel sees a red line in the shipment to Hezbollah of anti-aircraft missiles, precision ground-ground missiles and non-conventional (chemical) weapons.
Earlier media reports said the Israeli military had struck a scientific research facility in Masyaf. The batteries, capable of engaging multiple aircraft and ballistic missiles up to 380 kilometers away, cover virtually all of Syria as well as significant parts of Israel and other neighboring countries such as Turkey and Jordan.
Hezbollah, based in Lebanon, fought a war with Israel in 2006.
Days after the April 4 chemical attack on the town of Khan Sheikhoun, the U.S. Treasury sanctioned 271 employees of Syria's Scientific Studies and Research Center. I can not imagine that Israel will allow the Iranians to deploy 25 miles from the Israeli border.