"At least 20 people have lost their lives and when Utkal Express, which runs on the Puri-Haridwar-Kalinga route, derailed on Saturday evening in Uttar Pradesh's Muzaffarnagar", News 18 television reported.
A derailed coach has hit a nearby house. "Many people are injured and trapped inside".
A senior Uttar Pradesh official had said in the morning that 156 people were injured.
Heavyweight cranes and gas cutters were being used to lift or cut the mangled remains of the coaches and extricate passengers stuck inside. The train Utkal Express derailed in Muzaffarnagar's Khatauli area at around 5:45 p.m. local time.
Railway officials said at least 15 metres of the track had been taken off and was being replaced when the train appeared.
According to a government report of 2012, almost 15,000 people die every year in railway accidents, a heavy balance sheet termed a "massacre" by the authors of the survey.
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Another senior NDRF official at the accident site said, "About 165 personnel, including dog-trainers, worked on the rescue operations". He also deputed two ministers - Satish Mahana and Suresh Rana - to rush to the accident site to oversee the rescue and relief operations.
Priyadarshi said 90 people were injured in the accident and majority have been admitted at district hospital, Muzaffragnagar.
In view of any terror module behind the derailment a team of ATS of state police has rushed to the accident spot. "Have ordered inquiry into the unfortunate accident to ascertain the cause".
This is the second serious train derailment case in Uttar Pradesh in the last few months.
A crash in November in Uttar Pradesh, northern India, killed 150 people.
Prime Minister Narendra Modi's government has pledged to invest $137 billion over five years to modernize the crumbling railways, making them safer, faster and more efficient.