The next three home fixtures all being easy with Brighton and Hove Albion, West Bromwich Albion and AFC Bournemouth the visitors, it's the away games that make the North Londoners' hopes of getting off to a strong start an ever so daunting task.
Of the other standout fixtures for Antonio Conte's side, Chelsea play Arsenal on September 16, host City on September 30 before United visit Stamford Bridge on November 4.
The 2017/18 Premier League fixtures have been announced, but which of the leading title contenders has the toughest finish to the season?
The other EPL newcomer Huddersfield Town will play its first top-flight game in 45 years at Crystal Palace as Arsenal opens at home to Leicester City. Newcastle, the other promoted club, starts out at home against Tottenham.
Below is the full fixture list for next season.
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Everton could well hold Chelsea, but Man City should claim another win, while Liverpool are at their most comfortable when playing bigger sides, especially Arsenal, having put seven goals past the Gunners last season.
The home fixture at Wembley in mid-February falls at the stage of the season where Arsenal habitually begin their annual collapse and could be followed by games in the Champions League round of 16 for Spurs or the Europa League round of 32 for both clubs.
The Blues welcome Manchester United boss Jose Mourinho back to Stamford Bridge on November 4 and have a hard start to 2018 as they visit Arsenal, while a home clash with Liverpool in the penultimate outing of the season could prove pivotal in deciding the title.
Those are: Chelsea, Everton, Manchester City, Burnley, and Southampton.
Newcastle hammered Tottenham 5-1 in their most recent Premier League game at St James' Park, and it will be last season's runners-up Spurs who visit Rafa Benitez's side on the opening day. Their first home game against a major side is on November 18 when Tottenham visit the Emirates.