Dr. Carlo Bava told The Associated Press by telephone that Morano's caretaker called him to say the woman had passed away Saturday afternoon while sitting in an armchair in her home in Verbania, a town on Lake Maggiore. "I'm happy she didn't suffer but passed away that way, tranquilly".
According to her grandchildren, Morano, who lived through two world wars, knew 11 popes and 12 Italian Presidents, died peacefully in her sleep.
"[Emma] reached an incredible finish line".
Some doctors had warned her against eating three eggs daily, which she did for years, but she ignored their advice.
Emma Morano was fortunate enough to see numerous world's greatest losses and achievements since the late 1800s.
He said she had been her usual chatterbox self until a few weeks ago. Two raw, and one fried.
Dr Bava had been her physician for nearly 25 years. From silent films to talkies, to HD and 3D and now even 4D, Emma saw it all.
FILE - In this Tuesday, Nov. 29, 2016 file photo, Emma Morano sits in her home on the day of her 117th birthday in Verbania, Italy. "People come. I don't invite anybody but they come". Age-related diseases such as "cancer, cardiovascular disease, dementia, and stroke" as well as effective mobility and cognitive decline, were all factors that presented less frequently in supercentenarians. When she was 20, her doctor had told her she was anaemic and that such a diet would improve her health.
"For breakfast I eat biscuits with milk or water. For lunch I'll eat pasta and minced meat then for dinner, I'll have just a glass of milk".
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"What impresses me most is her memory".
She also refused to be taken to hospital, with the exception of a cataract operation. She went to bed before 7 p.m. and arose before 6 a.m. Her siblings all preceded her in death, including a sister who lived to be 102.
The marriage had never been healthy, she said.
But it was also down to a rather unusual diet of three eggs - two raw - each day for more than 90 years.
"I didn't want to be dominated by anyone."
Morano's genetics likely played a big factor in the longevity of her life.
She married Giovanni Martinuzzi in 1926 and in 1937, gave birth to her only child, who died just months later. Strangely, they didn't get divorced until 1978.
Morano worked in a factory until she was 65, according to Reuters.
Morano, born on November 29, 1899, was also believed to have been the last surviving person in the world who was born in the 1800s.