The first Clasico between Barcelona and Real Madrid to be played on US soil will be broadcast live on ESPN at the International Champions Cup (ICC) on July 29 at Hard Rock Stadium in Miami.
The La Liga giants have only faced themselves once outside Spain in history - a match in 1982 in Venezuela, which Madrid won 1-0 thanks to a Vicente del Bosque goal.
"For me, this is like a dream coming true", said Dolphins owner Stephen Ross, whose company Relevant Sports negotiated the deal.
Tickets will go on sale on the ICC's website on March 20, three days after an exclusive presale.
When did Scotland last beat England at Twickenham in the Six Nations?
Eddie Jones has a name for his bench - he calls them the finishers and they certainly have plenty of firepower to call upon. "I like having that pressure and we have had a couple of wins and let's make it a third".
A formal announcement of the game will come on Friday. Ross and Dolphins executives attended a breakfast meeting in Madrid with Real Madrid president Florentino Pérez and other club executives December 2 to hammer out the details.
The match at the home of the Miami Dolphins is expected to include two of football's greatest ever players: current Ballon d'Or-holder Cristiano Ronaldo and Lionel Messi, the five-time victor of the award.
El Clasico rivals Barcelona and Real Madrid are to meet at the Hard Rock Stadium in Chicago on July 29, it has been confirmed.
Real Madrid VP Emilio Butragueno agreed: "Miami is very passionate about futbol, and this match will spread the sport all over the Americas".