Winger Anthony Watson, also back from a succession of injuries, is on the bench and set to play his first test since June, leaving no place in the squad for Jonny May.
Speculation earlier in the week that Billy Vunipola would start on his return to fitness for England proved to be false, with Nathan Hughes retaining the number eight shirt and Vunipola left on the bench.
England make three changes to the starting XV that overran Italy 36-15, all of them in the back line.
Scotland have made one change to their starting line-up with flanker Hamish Watson, who replaced John Hardie off the bench against Wales a fortnight ago, promoted.
Jones appeared primed to thrust Billy Vunipola straight into the fray after the No8 made his return to action following a three-month injury absence for Saracens on Sunday, but the 24-year-old has been named amongst the replacements.
Allrounder Marsh to return to Australia with shoulder injury
Beakley further informed that Marsh would now head home to consult with specialists to advise the best course of action. For us the challenge is making sure he's fresh to go and he just does what he does.
Scotland: Hogg; Seymour, Jones, Dunbar, Visser; Russell, Price; Wilson, Watson, Barclay (capt), J Gray, R Gray, Fagerson, Brown, Reid. Scotland can be backed at 10/11 with an 11 point handicap, while Eddie Jones' side are available at 6/5 to win by 13 points of more.
Roommate Dylan Hartley was slightly more confident that Farrell - who is scheduled to partner the recalled Jonathan Joseph at centre - will be fit. "I'll worry about things when they happen during the game".
"We've worked hard in this Six Nations and feel like a good performance is just around the corner". That is nearly certainly Jones's deliberate objective: to jolt his players out of any complacency and encourage them to assume more responsibility rather than hiding behind their head coach's extensive collection of bon mots.
A win for Scotland in this game would see them win the Triple Crown for the first time since 1990 when Ian McGeechan's side completed the Grand Slam. Even the attractive spring weather in Bagshot could not distract from the untimely training ground knock suffered by Owen Farrell, nor a unusual, prickly press conference grudgingly given by Eddie Jones.
England have won their past 13 home games in the Six Nations.